Advancing age is a risk factor for feline renal failure. In most cats a specific cause cannot be determined. It is a progressive disease and the result of several diseases or insults to the kidney over a prolonged period of time.
The most common cause of chronic renal failure is a combination of accumulation of:
- scar tissue (fibrosis)
- cellular degeneration
- oxidative stress
- chronic inflammation called interstitial nephritis.